Equipment for Liposomes & LNP Production

Lipex Extruders (1 mL, 10mL, 100mL and  800 mL) for the production of liposomes with precisely controlled particle sizes across varied bench-scale volumes.

Custom-engineered large-scale extrusion system capable of 20kg batch sizes, utilizing pleated cartridge membranes for robust process scale-up toward commercial-grade production.

High-performance Branson Sonifier 450 ultrasonic processor equipped with a range of specialized probes, precision-tailored for the efficient processing of liposome formulations across various batch sizes.

Precision microfluidic self-assembly platform for the controlled and reproducible production of mRNA LNPs.

Automated Tangential Flow Filtration system for scalable concentration and high-efficiency buffer exchange of large batches (10kg capacity).

Automated Tangential Flow Filtration system for scalable concentration and high-efficiency buffer exchange of large batches (50mL-1L).

Multimodal High-resolution Dynamic Light Scattering (DLS) for precise measurement of particle size, PDI, and Zeta Potential).

Real-time Nanoparticle Tracking Analysis to determine absolute particle concentration and high-resolution size distribution.

Advanced laboratory configuration combining a high-pressure, flexible Thermo Scientific Ultimate 3000 UHPLC system and a Thermo Scientific Vanquish platform. Both systems are set for quantification of diverse active payloads and non-chromophoric lipids, utilizing orthogonal CAD/UV detection.

High-throughput fluorescence and absorbance screening for rapid validation of mRNA encapsulation efficiency and precise quantification of diverse fluorophores.

Versatile SpectraMax microplate readers (UV & fluorescence) for routine potency assays and biochemical characterization of formulation batches.

High-sensitivity Differential Scanning Calorimetry to monitor lipid phase transitions and the structural stability of proteins and nucleic acids.

Isothermal Titration Calorimetry (ITC): Label-free analysis of molecular binding affinities and thermodynamic profiles for ligand-target interactions.

High-precision analytical balances are used for accurate weighing of lipids, reagents, and drug compounds. Precise mass measurements are essential for reproducible formulations and accurate HPLC sample preparation.

Precision vapor pressure osmometry for the rapid, accurate determination of solute osmolality in complex liposomal and LNP formulations.

Advanced negative-pressure isolator equipped with HEPA filtration to provide maximum operator protection during high-containment material handling.

Advanced lyophilization system with integrated stoppering for the development of stable, long-term shelf-life drug products.

High-performance ultracentrifuge engineered for precision high-speed separations, featuring advanced vacuum systems and integrated digital controls for reliable sample processing.